DSS is very powerful and the defaults settings are very good.
I just choose the "RGB channel alignment" and the cosmetic pixels removal (1pixel and 50%). The two background calibration are good! anyway, you will have to do a color balance, at the end, in order to choose the final "look" that you prefer
After that, when the frames registration is finished (thanks to the "score" parameter), I always have a look to the FWHM of the best frames and I always check visually the best frames I plan to keep.
and that's all, at least for me!
ps: Don't forget to remove the offset frames! (dark removal for APN is not necessary, at least for short exposure time)